Are mesenchymal stem cells in rheumatoid arthritis the good or bad guys? Arthritis Research & Therapy (2015) 17:113 Rheumatoid arthritis: Stress in RA: a trigger of proinflammatory pathways? Nat Rev Rheumatol 10, 516–518 Mesenchymal stem cells alleviate experimental rheumatoid arthritis through microRNA-regulated IκB expression. As of March 20th, 2019, () showed 6 ongoing clinical trials to evaluate the safety and efficacy of umbilical cord mesenchymal stem cells for the treatment of rheumatoid arthritis. 4,6,7 Research is ongoing, but with the urgent need for more effective treatments for Rheumatoid arthritis, particularly for those patients with the more progressive forms of the disease, the Stem Cells Transplant Institute believes the potential of all types of cell therapies must be explored. Results showed patients treated with mesenchymal stem cells had better efficacy than those patients in the control arms. Stem cell therapy for rheumatoid arthritis has been found to be safe.4,5 In two clinical trials, 225 patients with rheumatoid arthritis were investigated for the efficacy of mesenchymal stem cells. Researchers are focusing on developing treatment options that would not only treat the symptoms associated with rheumatoid arthritis, but also repair and replace the damaged tissue while reducing inflammation and preventing future tissue damage. What are researchers investigating? Can stem cell therapy improve the symptoms of RA? Joints that have already been damaged will not heal, but further damage may occur.Even with the resolution of inflammation, joint injury may persist.Up to 30% of patients fail to respond to current treatment options. Rheumatoid arthritis increases the risk of developing other serious health problems, such as:ĭespite advances in FDA approved treatments, the following issues continue to exist: This condition also affects non-joint structures such as the skin, eyes, kidneys, blood vessels, nerve tissue, bone marrow, the heart, and lungs.Īlthough the exact cause of the disease is unknown, researchers believe it is caused by a combination of genetic and environmental factors. In approximately 40% of people diagnosed with rheumatoid arthritis, the inflammation can affect more than just the joints. Rheumatoid arthritis occurs when the immune system mistakenly attacks the synovium, resulting in inflammation and thickening of the synovium, eventually destroying the cartilage and bone within the joint.Īs the tendons and ligaments holding the joint together get damaged, the joint is no longer supported. The immune system is supposed to protect healthy tissue from foreign invaders such as bacteria, viruses, and germs. It causes the destruction of the articular cartilage, resulting in pain, stiffness, and inflammation of the synovial membrane (the healthy tissue membrane that surrounds the joints). Rheumatoid arthritis is a chronic autoimmune and inflammatory disease that primarily affects the joints. What do we know about rheumatoid arthritis? Once at these damaged tissue sites, MSCs can exert both protective cellular effects believed to be critical in many musculoskeletal conditions. Evidence suggests MSCs can enter the circulating blood during injury and have been shown to readily home to areas of injury or inflammation. In addition to HSCs, mesenchymal stem cells (MSCs) are also contained within BM. Evidence suggests that BM-derived monocytes may act to improve certain musculoskeletal conditions. These include red blood cells and white blood cells (such as monocytes). Hematopoietic stem cells (HSCs), found within BM, are the body’s source of most cells found in the peripheral or circulating blood. There are multiple inherent benefits afforded by the utilization of bone marrow derived stem cells as Bone marrow (BM) and bone marrow components function in various diverse, innate therapeutic capacities. TruStem Cell Therapy provides access to treatment that utilizes a patient’s stem cells isolated from their own bone marrow.
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